DOBUZEF

GENERIC NAME:

Dobutamine HCl (Hydrochloride)

FORM:

Solution for Injection (IV Infusion)

FORMULATION:

Each mL contains Dobutamine (as Hydrochloride) – 50mg

INDICATION AND USAGE:

It is used to increase the contractility of the heart in acute heart failure, as occurs in cardiogenic shock and myocardial infarction. It is also useful during cardiac surgery and positive end expiratory pressure ventilation.

DOSAGE and ADMINISTRATION:
Dobutamine is given as the hydrochloride but doses are expressed in terms of the base: 1.12 micrograms of the hydrochloride is approximately equivalent to 1 microgram of base.
It is administered by intravenous infusion as a dilute solution (0.25 to 5mg/ mL) in Glucose 5% or Sodium Chloride 0.9%; Other fluids may also be suitable.
In the management of acute heart failure, dobutamine is given at a usual rate of 2.5 to 10 micrograms/kg per minute, according to the patient’s heart rate, blood pressure, cardiac output and urine output. A range of 0.5 up to 40 micrograms/kg per minute has occasionally been required. It has been recommended that the treatment with dobutamine should be discontinued gradually.
Dobutamine is also used as an alternative to exercise in cardiac stress testing. A solution containing 1 mg/mL is employed for this purpose, given via an infusion pump. A dose of 5 micrograms/kg per minute is infused for 8 minutes; the dose is then increased by increments of 5 micrograms/kg per minute up to a usual maximum of 20 micrograms/kg per minute, with each dose being infused for 8 minutes before the next incremental increase of doses up to 40 micrograms/kg per minute has sometimes been used. The ECG should be monitored continuously and the infusion terminated if arrythmias, marked ST segment depression, or other adverse effect occurs.
Or as prescribed by the physician.

AVAILABILITY:

Clear and colorless glass ampoule x 5mL in transparent plastic tray; (Box of 5’s)

Description

DOBUZEF

Dobutamine Hydrochloride

50 mg/mL (250mg / 5mL)

Solution for Injection / For I.V. use only

Adrenergic Agent

ADVISORY: DOBUZEF is a prescription medicine. Consult your physician and other healthcare providers before taking this medicine. The content of this page is to provide information only. It is not construed as a substitute for a professional medical advice and should not be relied upon in that regard. You must undertake to carefully read all product packaging and labels prior to use.